“Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?”
– (Hat Tip, Margaret @ Margaret’s Corner, see sidebar for blog link)
Appeared in Blood Journal October 20, 2010
Abstract:
Many trials in myeloma are stratified on cytogenetic abnormalities. Among them, the most commonly chosen are the t(4;14), the del(17p), and the t(14;16). If data are well established for t(4;14) and del(17p), very few data support the use of t(14;16). In order to address this issue, we retrospectively analyzed 1003 patients with newly diagnosed myeloma for this abnormality. We identified 32 patients with the t(14;16). When compared with patients lacking the t(14;16), we did not observe any difference in overall survival (p=.28). Moreover, in multivariate analyses, the t(14;16) was neither prognostic (p=.39). In conclusion, our data do not support the use of t(14;16)-specific probes in the diagnostic panels of multiple myeloma.
Translocation(14,16) (.pdf of paper)
